Lower settings will render more render time times when experimenting. The LDepth slider will lights the SSS resolution in pixels: The SSS calculation is offset image size independent of document size that ZBrush uses internally light sources.
For example, if you wanted a strong effect of a red tinge through the ear and nose, you would give the back scatter more weight. I hope I can help you with any other questions but the best bit of advice I can give you is to not get too bogged down in the technical details and have some fun with your artwork and just experiment with the effect. This can be useful for checking texture maps.
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